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What actually works

Every way to improve your looks, with the evidence behind it, how long it takes and whether you need a prescription.

What works

Ways to improve and what each one does. Evidence: Strong means large trials or medical consensus, Moderate means smaller studies, Weak means early or mixed results. Rx means you need a prescription.

Skin

MethodEvidenceTime to seeAccess
Sunscreen, SPF 30+

Prevents the sun damage behind most wrinkles, spots and uneven tone.

StrongOngoingOTC
Tretinoin

Speeds skin turnover: clears acne, smooths texture, softens fine lines.

Strong3–6 monthsRx
Adapalene

A gentler retinoid for acne and clogged pores.

Strong8–12 weeksOTC
Azelaic acid

Calms redness, treats acne and fades dark marks.

Moderate8–12 weeksOTC / Rx
Salicylic acid (BHA)

Gets inside pores to clear blackheads and oil.

Moderate4–6 weeksOTC
Niacinamide

Evens tone, reduces oiliness and supports the skin barrier.

Moderate4–8 weeksOTC
Isotretinoin

Treats severe acne, often for good, after one course.

Strong4–6 monthsRx + monitoring
Microneedling (clinic)

Tiny punctures trigger repair, which improves acne scars and texture.

Moderate3+ sessionsClinic

Hair

MethodEvidenceTime to seeAccess
Minoxidil

Slows hair loss and regrows some hair. Expect a shed at first.

Strong3–6 monthsOTC
Finasteride

Blocks the hormone (DHT) behind male hair loss and stops it in most men.

Strong6–12 monthsRx
Ketoconazole shampoo

Clears dandruff and may slightly help thinning hair.

Weak–moderate4–8 weeksOTC
A cut for your face shape

The fastest visible change you can make.

StrongSame dayBarber

Body

MethodEvidenceTime to seeAccess
Fat loss (calorie deficit)

Shows your jawline and cheekbones and tightens your whole look.

Strong8–16 weeksFree
Resistance training

Builds shoulders and back for a V-taper and better posture.

Strong8–12 weeksGym
Protein 1.6–2.2 g/kg

Keeps and builds muscle while you lean out.

StrongOngoingFood
Creatine monohydrate

More strength and muscle when paired with training.

Strong3–4 weeksOTC
7–9 hours of sleep

Less puffiness and fewer dark circles, plus better recovery.

StrongDaysFree
8–10k steps a day

Easy fat loss, and it doesn't eat into your recovery.

ModerateWeeksFree

Face & smile

MethodEvidenceTime to seeAccess
Brow and beard shaping

Frames the face and makes it look more defined.

StrongSame dayBarber
Teeth whitening

Brightens your smile with dentist or approved peroxide strips.

Strong1–2 weeksOTC / dentist
Clear aligners or braces

Straightens teeth and can improve how your lips and profile sit.

Strong6–24 monthsOrthodontist
Glasses that fit your face

The right frame balances your face shape.

ModerateSame dayOptician

Peptides

Peptides are short chains of amino acids. Some are well-studied skincare ingredients or prescription drugs. Others are injectable “research chemicals” that aren't approved for people, often with unknown purity. Ascend doesn't share doses or sources for unapproved peptides. Talk to a doctor before taking anything, and if you're under 18, skip anything prescribed or injected.

MethodEvidenceTime to seeAccess
Copper peptide (GHK-Cu), topical

Claimed to firm skin and help repair. Evidence is mostly lab work and small studies.

Weak–moderate8–12 weeksOTC
Signal peptides (e.g. Matrixyl), topical

May soften fine lines. The trials are small and often industry-funded.

Weak–moderate8–12 weeksOTC
Collagen peptides, oral

Modest gains in skin hydration and elasticity in reviews. Quality varies by brand.

Moderate8–12 weeksSupplement
GLP-1 drugs (semaglutide, tirzepatide)

Strong weight loss. Side effects include nausea and muscle loss without enough protein and training.

StrongMonthsRx only
BPC-157 / TB-500

Claimed to speed healing and recovery. Evidence comes from animal studies only, and the FDA has flagged BPC-157 as a safety concern.

Animal onlyn/aUnapproved
GH boosters (CJC-1295, ipamorelin)

Claimed to increase growth hormone for fat loss and skin. There's little human evidence, and risks include water retention and higher blood sugar.

Weakn/aUnapproved
Melanotan II

An injectable tanning drug. It's linked to new or changing moles and nausea, and health agencies warn against it.

Riskyn/aUnapproved
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